Announcing the Cardiovascular Disease Knowledge Portal
We are pleased to announce the launch of the Cardiovascular Disease Knowledge Portal (CVDKP). Our collaboration with Dr. Patrick Ellinor, Dr. Sek Kathiresan, and their colleagues in the Atrial Fibrillation, Global Lipids Genetics, Myocardial Infarction Genetics, and CARDIoGRAMPlusC4D consortia has created a resource that offers world-wide open access to genetic and genomic information about atrial fibrillation, myocardial infarction, and related traits, with the goal of democratizing access to genomic data and accelerating cardiovascular genomics research.
The CVDKP is constructed on a software architecture originally developed for the Type 2 Diabetes Knowledge Portal (T2DKP), which is the central product of the Accelerating Medicines Partnership in Type 2 Diabetes (AMP T2D). AMP T2D is a public-private partnership between the National Institutes of Health, the U.S. Food and Drug Administration, biopharmaceutical companies, and non-profit organizations that is managed through the Foundation for the NIH. AMP seeks to harness collective capabilities, scale, and resources toward improving current efforts to develop new therapies for complex, heterogeneous diseases.
The ultimate goal of AMP T2D is to increase the number of new diagnostics and therapies for patients while reducing the time and cost of developing them, by jointly identifying and validating promising biological targets for type 2 diabetes. The T2DKP furthers that goal by aggregating, harmonizing, and displaying genetic association and epigenomic results along with user-friendly analysis tools, allowing research biologists who would not individually be able to amass and manipulate these large datasets to glean insights from the data.
We are working towards these same goals for other complex diseases, by extending the platform and analysis tools constructed for the T2DKP. In partnership with the International Stroke Genetics Consortium, we recently created a Knowledge Portal for cerebrovascular disease (CDKP) based on the same infrastructure. Now, with the advent of the Cardiovascular Disease Knowledge Portal, we have a three-member Knowledge Portal Network for the genetics of cardiometabolic and cerebrovascular disease.
Data in the CVDKP directly relevant to heart disease include genetic associations with atrial fibrillation, electrocardiogram traits, plasma lipid levels, and myocardial infarction. Additional association datasets are available for type 2 diabetes and glycemic traits, anthropometric traits, measures of kidney function, and psychiatric traits. You may browse the complete list of datasets and their descriptions on the CVDKP Data page.
As for the Cerebrovascular Disease Knowledge Portal, in the CVDKP we also continue to work with the American Heart Association Precision Medicine Platform (PMP) to provide an additional avenue for accessing cardiovascular genetic data. Currently, summary statistics from the AFGen GWAS and AFGen exome chip analysis datasets are deposited in the PMP.
We welcome all suggestions, comments, questions, and submission of relevant datasets for the CVDKP. Please contact us at cvdgenetics@gmail.com!
The CVDKP is constructed on a software architecture originally developed for the Type 2 Diabetes Knowledge Portal (T2DKP), which is the central product of the Accelerating Medicines Partnership in Type 2 Diabetes (AMP T2D). AMP T2D is a public-private partnership between the National Institutes of Health, the U.S. Food and Drug Administration, biopharmaceutical companies, and non-profit organizations that is managed through the Foundation for the NIH. AMP seeks to harness collective capabilities, scale, and resources toward improving current efforts to develop new therapies for complex, heterogeneous diseases.
The ultimate goal of AMP T2D is to increase the number of new diagnostics and therapies for patients while reducing the time and cost of developing them, by jointly identifying and validating promising biological targets for type 2 diabetes. The T2DKP furthers that goal by aggregating, harmonizing, and displaying genetic association and epigenomic results along with user-friendly analysis tools, allowing research biologists who would not individually be able to amass and manipulate these large datasets to glean insights from the data.
We are working towards these same goals for other complex diseases, by extending the platform and analysis tools constructed for the T2DKP. In partnership with the International Stroke Genetics Consortium, we recently created a Knowledge Portal for cerebrovascular disease (CDKP) based on the same infrastructure. Now, with the advent of the Cardiovascular Disease Knowledge Portal, we have a three-member Knowledge Portal Network for the genetics of cardiometabolic and cerebrovascular disease.
Data in the CVDKP directly relevant to heart disease include genetic associations with atrial fibrillation, electrocardiogram traits, plasma lipid levels, and myocardial infarction. Additional association datasets are available for type 2 diabetes and glycemic traits, anthropometric traits, measures of kidney function, and psychiatric traits. You may browse the complete list of datasets and their descriptions on the CVDKP Data page.
As for the Cerebrovascular Disease Knowledge Portal, in the CVDKP we also continue to work with the American Heart Association Precision Medicine Platform (PMP) to provide an additional avenue for accessing cardiovascular genetic data. Currently, summary statistics from the AFGen GWAS and AFGen exome chip analysis datasets are deposited in the PMP.
We welcome all suggestions, comments, questions, and submission of relevant datasets for the CVDKP. Please contact us at cvdgenetics@gmail.com!
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