Cardiovascular Disease Knowledge Portal News

We've added a new dataset to the Cardiovascular Disease Knowledge Portal: PR interval exome chip analysis, with genetic associations from nearly 93,000 individuals. This study was published yesterday in Circulation: Genomics and Precision Medicine ( Lin, H., et al.,  Circ Genom Precis Med. 2018;11:e002037 ). The cardiac conduction system is critical to proper heart function, and abnormalities are associated with harmful conditions such as atrial fibrillation. One measure of cardiac conduction is the duration of the PR interval, defined as the time between the onset of the P wave and the onset of the QRS interval in an electrocardiogram. In this study, the authors measured the PR interval, in milliseconds, for 83,367 participants of European ancestry and 9,436 participants of African-American ancestry. They genotyped each participant using the Illumina Human Exome BeadChip, analyzed variant associations with PR interval, and performed meta-analyses. Common and low-frequency vari

At the Knowledge Portal Network (currently consisting of the Type 2 Diabetes , Cerebrovascular Disease , and Cardiovascular Disease Knowledge Portals), we are looking for energetic, talented people to help us produce web portals that aggregate and serve genetic association results to the world in order to spark insights into complex diseases. There are positions open for a software engineer to help in developing and producing these web portals, and for a technical release manager to manage and coordinate tasks during production and maintenance of the portals. The positions are located at the Broad Institute in Cambridge, MA, a dynamic and exciting work environment where cutting-edge science is applied to critical biomedical problems. Find more details and apply for the  software engineer  or  technical release manager  positions at the  Broad Careers  site.