Large new atrial fibrillation dataset now in the CVDKP
With today's publication of a new large-scale genetic association study ( Roselli et al., Multi-ethnic genome-wide association study for atrial fibrillation, Nature Genetics (2018) doi:10.1038/s41588-018-0133-9), the corresponding dataset has been incorporated into the Cardiovascular Disease Knowledge Portal (CVDKP). The new dataset, named 2018 AF HRC GWAS in the CVDKP, surveys more than 500,000 individuals, including over 65,000 with atrial fibrillation. With the majority of samples imputed to the Haplotype Reference Consortium (HRC) reference panel, the study analyzed associations for a total of more than 8 million common variants, nearly 3 million low-frequency variants, and almost 1 million rare variants. Individuals in the study represented a wide range of ancestries, including African American, East Asian, Hispanic, and Brazilian in addition to European. With such a large sample size, the study had the power to detect many new associations. While about 30 loci associate