New PR interval genetic associations in the CVDKP

We've added a new dataset to the Cardiovascular Disease Knowledge Portal: PR interval exome chip analysis, with genetic associations from nearly 93,000 individuals. This study was published yesterday in Circulation: Genomics and Precision Medicine (Lin, H., et al., Circ Genom Precis Med. 2018;11:e002037).

The cardiac conduction system is critical to proper heart function, and abnormalities are associated with harmful conditions such as atrial fibrillation. One measure of cardiac conduction is the duration of the PR interval, defined as the time between the onset of the P wave and the onset of the QRS interval in an electrocardiogram. In this study, the authors measured the PR interval, in milliseconds, for 83,367 participants of European ancestry and 9,436 participants of African-American ancestry. They genotyped each participant using the Illumina Human Exome BeadChip, analyzed variant associations with PR interval, and performed meta-analyses.

Common and low-frequency variants (minor allele frequency ≥ 1%) were analyzed separately from rare variants (minor allele frequency < 1%). These analyses identified 31 loci in which common variants were significantly associated with PR interval, and two loci with significant rare variant associations.

You can now explore the summary results from this study in the CVDKP, in several different ways. The dataset is described on our Data page, and summary results may be seen:

On Gene pages (see an example) on the Common variants and High-impact variants tabs

On Variant pages (see an example) in the Associations at a glance section and the Association statistics across traits table

Via the Variant Finder search

View a Manhattan plot of associations across the genome by selecting "PR interval" in the View full genetic association results for a phenotype menu on the home page.

We are pleased to provide access to these important new results. Please contact us with any questions or comments about these new data or the CVDKP in general!


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