Heart failure and albuminuria associations across nearly 400,000 UK Biobank subjects now available in the CVDKP
Two new datasets now bring associations for heart failure and albuminuria from large UK Biobank subject pools to the Cardiovascular Disease Knowledge Portal (CVDKP). Both studies revealed important insights about the etiology of different aspects of cardiovascular disease. And the results of both studies are available now in the CVDKP--both integrated into the Portal, and as files of summary statistics for download. The study of heart failure associations ( Aragam et al. (2018), Circulation ) looked at associations both with heart failure from any cause and with a more refined phenotype, nonischemic cardiomyopathy (NICM), defined as left ventricular dysfunction without coronary artery disease. The loci significantly associated with all-cause heart failure were predominantly those already known to be associated with heart failure risk factors, such as coronary artery disease and atrial fibrillation. However, refining the phenotype to NICM revealed a different spectrum of associatio